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KMID : 0363420090230030263
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Journal of Korean Oriental Pediatrics
2009 Volume.23 No. 3 p.263 ~ p.291
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Effect of Yanghyeoljeseuptang (YHJST) Composition on Atopic Dermatitis NC/Nga Mice Induced by DNCB(dinitrochlorobenzene)
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Park Doo-Byoung
Han Jae-Kyung
Kim Yun-Hee
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Abstract
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Objectives: The purpose of this study is to investigate the effect of YHJST on atopic dermatitis in an experiment
using an NC/Nga mice induced by DNCB, which has histological and clinical similarities to the condition in humans.
Methods: To investigate the effect of YHJST on atopic dermatitis(AD), we evaluated atopic dermatitis-like skin lesions by clinical skin index and analyzed immunological parameters in peripheral blood mononuclear cells(PBMCs) and performed skin histology in ears and dorsal skin of NC/Nga ato-mouse.
Results: YHJST medicines decreased Serum level of IgE, IL-6, TNF-α. Also total number of CD69+, CD3+ in PBMCs, absolute cell number of CCR3+CD3+, CD11b+Gr-1+ in Dorsal skin tissue, Serum IgG1, IgM, IgG2a and IgG2b decreased significantly. Furthermore YHJST is extremely effective to histological symptoms; dermal and epidermal thickening, hyperkeratosis and inflammatory cell infiltration and suppressed histologic infiltration of CD4+& CCR3+ in ear and dorsal skin lesions significantly. YHJST decreased gene-expression of IL-6, TNF-α, CCR3, Eotaxin mRNA than that of control group.
Conclusions: YHJST on atopic dermatitis to atopic dermatitis NC/Nga mouse induced DNCB was incredibly effective.
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KEYWORD
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atopic dermatitis, Yanghyeoljeseuptang, NC/Nga mouse
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